Collect Red Top, Lavender EDTA, Sodium Heparin or Sodium Fluoride. Spin, separate serum/plasma from cells within 2 hours. Transfer 2.0 mL serum/plasma to screw top transport tube, indicate specimen type on transport tube and freeze. Send on dry ice.
Submit with order: Dose (list drug amount and include the units), Route (IV vs oral), Dose Frequency (per day/week or as needed) and Type of draw (peak, trough, random etc).
Quantitative Liquid Chromatography - Tandem Mass Spectrometry
Frozen: 14 days
9-11 days, Performed Mondays
The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Toxic concentrations may cause mental confusion, cardiac abnormalities and seizures. Concentrations below 25 ng/mL may have no effect. This method does not quantify the major metabolite, hydroxybupropion.