PROTEIN ELECTROPHORESIS, URINE RANDOM
Collect first morning urine, send 20 mL in a sterile container, minimum 6 mL.
Preservative is not acceptable.
Electrophoresis on agarose media
Room temp: Unacceptable, Refrigerated: 3 days, Frozen: 30 days
Evaluate myeloma, macroglobulinemia of Waldenström, lymphoma, amyloidosis; differentiate between normal renal function, glomerular proteinuria, and tubular proteinuria. Increased glomerular permeability leads to higher concentrations of large proteins in the glomerular filtrate. Diminished tubular reabsorptive capacity results in a marked increase in urinary excretion of low molecular weight problems.