HIV-1 Resistance, Proviral DNA (RTI, PI, Integrase Inhibitors) (GENOSURE)
4 mL plasma collected in an EDTA (lavender top) or PPT (white top) tube
ALSO KNOWN AS GENOSURE PRIME
Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) • Sequencing
Room temperature: 24 hours Refrigerated: 6 days Frozen: 42 days
5-7 Days; Performed Tues, Sat
This test utilizes PCR and next generation (ultra-deep) sequencing of proviral DNA to detect drug resistance mutations in the HIV-1 protease, reverse transcriptase and integrase genes. This information will assist clinicians considering a modification of the treatment regimens for virologically suppressed patients or for patients with a low viral load for whom an RNA resistance test was not successful.