Collect red top or lavender (EDTA), send 4.0 mL serum/plasma. Centrifuge, transfer serum/plasma to a plastic transport tube, indicate sample type on tube and send.
Alternate sample: Green top Heparin
Do not use gel barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Room temp: 14 days, Refrigerated: 14 days, Frozen: 14 days
Half-life is 15 to 40 hours. Haloperidol is an antipsychotic tranquilizer used to control acute and chronic psychotic disorders, for the control of Tourette syndrome, and for the treatment of severe behavior problems in hyperactive children. Haloperidol is metabolized by dealkalization, oxidation, and conjugation; the hydroxy derivative is active but concentrations are very low. Haloperidol should be monitored to assess and optimize dosing regimens and maintenance therapy since the relationship between dosage and serum levels at steady-state can be highly variable. The drug should also be monitored to assess adverse reactions and changes associated with co-administered drugs.