Specimen Requirements


Creatine Kinase – MB, (CK-MB)

Specimen Requirement

1 SST/1.0 mL serum. After 30 minutes of clotting, promptly centrifuge and refrigerate.



Refrigerated: 48 hours; Frozen: 3 months

Reference Range

By Report


1 day

Clinical Use

The quantitation of CK-MB levels in serum is used as an aid in the diagnosis of myocardial injury. Elevated CK-MB levels are associated with myocardial cell death and damage due to acute myocardial infarction (AMI). CK-MB levels can be detected as a result of myocardial injury within 3 to 8 hours following the onset of chest pain with peak concentrations being achieved within 12 to 24 hours and usually returning to baseline levels within 24 to 48 hours.

Test Code