Specimen Requirements
Title
Alpha-1-Antitrypsin Phenotype
Specimen Requirement
Collect SST/1.0 mL serum, after 30 minutes of clotting, promptly centrifuge and send refrigerated.
Methodology
Isoelectric Focusing/Nephelometry
Stability
Room temp: Unacceptable, Refrigerated: 7 days, Frozen: 14 days
Reference Range
By Report*
Turnaround
1-4 days, Performed Tuesday, Friday
Clinical Use
More than 40 phenotypes of AAT exist. The inherited deficiency, seen most often as the ZZ, SS and SZ phenotypes, is associated with neonatal hepatitis and infantile cirrhosis. In adults, these phenotypes are associated with chronic lung disease, including emphysema and chronic bronchitis.
Test Code
A1APW