Anti Cytoplasmic Ab (ANCA)
1 SST/2.0 mL SERUM. AFTER 30 MINUTES OF CLOTTING, PROMPTLY CENTRIFUGE AND REFRIGERATE SERUM. (INCLUDES EVALUATION FOR P-ANCA, C-ANCA AND ATYPICAL P-ANCA)
ROOM TEMPERATURE: 7 DAYS; REFRIGERATED: 14 DAYS; FROZEN: 30 DAYS
WITHIN 3 DAYS/SET UP: TUES-SAT A.M.
C-ANCA are present in 84-100% of patients with generalized Wegener granulomatosis (WG). C-ANCA-positive sera containing PR-3 Abs are 80% sensitive and 97% specific for WG. Positive ANCA results obtained in patients with other types of vasculitis typically give a PANCA pattern and are usually associated with autoantibodies to myeloperoxidase (MPO).