Specimen Requirements

Title

AMINOLEVULINIC ACID(ALA),URINE

Specimen Requirement

Methodology

Stability

Room tenp: unacceptable; Refrigerated 4 days; Frozen: 1 month

Reference Range

By report

Turnaround

4-6 days

Clinical Use

Diagnose porphyrias: delta-ALA may be increased in attacks of acute intermittent porphyria, hereditary coproporphyria, and porphyria variegata; evaluation of certain neurological problems with abdominal pain; diagnosis of lead or mercury poisoning. Urinary delta-ALA is not a sensitive indicator of lead poisoning in children because it does not increase until blood lead concentration is 40 µg/dL, well above the recommended level of <15 µg/dL. ALA is increased also in tyrosinemia.1,2 Porphobilinogen and delta aminolevulinic acid are the tests of choice for acute intermittent porphyria. Recently the molecular lesions have been identified in a severely affected homozygote with delta aminolevulinate dehydratase deficient porphyria .

Test Code

ALA